Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2
نویسندگان
چکیده
منابع مشابه
Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2
C-type lectins dectin-1 and dectin-2 on dendritic cells elicit protective immunity against fungal infections through induction of T(H)1 and T(H)-17 cellular responses. Fungal recognition by dectin-1 on human dendritic cells engages the CARD9-Bcl10-Malt1 module to activate NF-κB. Here we demonstrate that Malt1 recruitment is pivotal to T(H)-17 immunity by selective activation of NF-κB subunit c-...
متن کاملMast cells Dectin-1 in innate anti-fungal immunity
Dectin-1 recognizes β-glucan and plays important roles for the anti-fungal immunity through the activation of Syk in dendritic cells (DCs) or macrophages. Recently, expression of Dectin-1 was also identified in human and mouse mast cells, although its physiological roles were largely unknown. In this report, rat mast cell line RBL-2H3 was analyzed to investigate the molecular mechanism of Decti...
متن کاملDectin-1 and Dectin-2 in innate immunity against fungi.
Dectin-1 and Dectin-2 are type II transmembrane proteins of the C-type lectin family with single carbohydrate recognition domains (CRDs) in their extracellular region. They are expressed mainly in dendritic cells and macrophages. Dectin-1 recognizes β-glucans with its CRD and transduces signals through its immunoreceptor tyrosine-based activation motif (ITAM)-like motif in the cytoplasmic domai...
متن کاملRecognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2.
The discovery of several transmembrane receptors expressed by antigen presenting cells, including those that detect and interact with specific sugar moieties on the surface of microbes, has improved our understanding of how immunity against infection is generated. This knowledge, in turn, prompted us to review such interactions with emphasis on C-type lectin receptors and a focus on the roles o...
متن کاملDectin-1 deficiency and mucocutaneous fungal infections.
n engl j med 362;4 nejm.org january 28, 2010 367 (HAPO) study.3,4 Fifteen institutional review boards approved our protocol, and none rejected the trial on ethical grounds. In addition, an independent data and safety monitoring committee regularly reviewed the trial. Some participants would not even have met the criteria for gestational diabetes (more evidence of clinical equipoise). We strongl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS Pathogens
سال: 2011
ISSN: 1553-7374
DOI: 10.1371/journal.ppat.1001259